Microfluidics

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Beschreibung

The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science.

As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials.

A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.



Yujun Song is a professor in School of Mathematics and Physics at USTB in Beijing, China, focusing on synthesis, interface structure control and application of metal-based nanohybrids using microfluidic process and template-assisted growth process. Having obtained his PhD degrees in Materials Science and Engineering from Beijing University of Chemical Technology, he spent 5 years at Louisiana State University in microfluidics and bio-nanotechnology, 2 years working at Old Dominion University in surface plasmon resonance and biotechnology, 7 years working at Beihang University in microfluidic synthesis and template-assisted growth process. He also spent one year working at University of Toronto as a visiting professor working on fabrication of hybrid semiconductor nanowire thin films, before taking up his present appointment at USTB.

Daojian Cheng is Professor at Department of Chemical Engineering, Beijing University of Chemical Technology, China. He has been named a Fellow of the Royal Society of Chemistry. He obtained his Ph.D. Degree in Chemical Engineering from Beijing University of Chemical Technology in 2008. During 2008-2010, he worked as a Postdoctoral Research Fellow at Universite Libre de Bruxelles, Belgium. Currently he has interests in theoretical study, computational design and experimental synthesis of metal clusters and nanoalloys as catalysts for renewable clean energy and environmental protection applications.

Liang Zhao is Assistant Professor at University of Science and Technology Beijing. Before that, he worked at Peking University as a postdoctoral associate (2010-2013). He received his PhD in Nanjing University in 2009. In 2014-2015, he was a visiting researcher in UC Berkeley, Prof. Luke Lee?s group. His research currently focuses on developing new microfluidic device which can be easily used to study cell patterning, tumor metastasis, tumor-stoma interactions, and organ on chip. He also works on single cell RNA-Seq in integrated microfluidic platform, which may bring some valuable merits such as high throughput and efficiency comparing with conventional way of molecular biology.



Autorentext
Yujun Song is a professor in School of Mathematics and Physics at USTB in Beijing, China, focusing on synthesis, interface structure control and application of metal-based nanohybrids using microfluidic process and template-assisted growth process. Having obtained his PhD degrees in Materials Science and Engineering from Beijing University of Chemical Technology, he spent 5 years at Louisiana State University in microfluidics and bio-nanotechnology, 2 years working at Old Dominion University in surface plasmon resonance and biotechnology, 7 years working at Beihang University in microfluidic synthesis and template-assisted growth process. He also spent one year working at University of Toronto as a visiting professor working on fabrication of hybrid semiconductor nanowire thin films, before taking up his present appointment at USTB.

Daojian Cheng is Professor at Department of Chemical Engineering, Beijing University of Chemical Technology, China. He has been named a Fellow of the Royal Society of Chemistry. He obtained his Ph.D. Degree in Chemical Engineering from Beijing University of Chemical Technology in 2008. During 2008-2010, he worked as a Postdoctoral Research Fellow at Universite Libre de Bruxelles, Belgium. Currently he has interests in theoretical study, computational design and experimental synthesis of metal clusters and nanoalloys as catalysts for renewable clean energy and environmental protection applications.

Liang Zhao is Assistant Professor at University of Science and Technology Beijing. Before that, he worked at Peking University as a postdoctoral associate (2010-2013). He received his PhD in Nanjing University in 2009. In 2014-2015, he was a visiting researcher in UC Berkeley, Prof. Luke Lee?s group. His research currently focuses on developing new microfluidic device which can be easily used to study cell patterning, tumor metastasis, tumor-stoma interactions, and organ on chip. He also works on single cell RNA-Seq in integrated microfluidic platform, which may bring some valuable merits such as high throughput and efficiency comparing with conventional way of molecular biology.



Inhalt

Preface xiii

Acknowledgments xv

Abbreviations xvii

1 Introduction: The Origin, Current Status, and Future of Microfluidics 1
Kin Fong Lei

1.1 Introduction 1

1.2 Development of Microfluidic Components 3

1.3 Development of Complex Microfluidic Systems 4

1.4 Development of Application-Oriented Microfluidic Systems 6

1.4.1 Applications of DNA Assays 6

1.4.2 Applications of Immunoassays 9

1.4.3 Applications of Cell-Based Assays 11

1.5 Perspective 14

References 14

2 Fundamental Concepts and Physics in Microfluidics 19
Yujun Song, Xiaoxiong Zhao, Qingkun Tian, and Hongxia Liang

2.1 Introduction 19

2.2 Basic Concepts of Liquids and Gases 21

2.2.1 Mean Free Path () in Fluids among Molecular Collisions 21

2.2.2 Viscosity () of Fluids 22

2.2.3 Mass Diffusivity (D) 29

2.2.4 Heat (Thermal) Capacity 34

2.3 Mass and Heat Transfer Principles for Fluid 41

2.3.1 Basic Fluidic Concepts and Law for Mass and Heat Transfer 42

2.3.1.1 Pascal's Law and Laplace's Law 42

2.3.1.2 Mass Conservation Principle (Continuity Equation) 44

2.3.1.3 Energy Conservation (Bernoulli's Equation) 44

2.3.1.4 Poiseuille's Law 45

2.3.1.5 Velocity Profile of Laminar Flow in a Circular Tube 46

2.3.2 Important Dimensionless Numbers in Fluid Physics 47

2.3.3 Other Dimensionless Numbers in Fluids 50

2.3.4 Diffusion Laws 56

2.3.5 Conversion Equation Based on NavierStokes Equations 59

2.3.5.1 Conservation of Mass Equation 60

2.3.5.2 Conservation of Momentum Equation (NavierStokes Equation) 61

2.3.5.3 Conservation of Energy Equation 62

2.4 Surfaces and Interfaces in Microfluidics 62

2.4.1 Surface/Interface and Surface Tension 62

2.4.2 Surface-/Interface-Induced Bubble Formation 66

2.4.3 Effect of Surfactants on the Surface/Interface Energy forWetting 68

2.4.4 Features of Surface and Interface in Microfluidics 69

2.4.5 Capillary Effects in Microfluidic Devices 70

2.4.6 Droplet Formation in Microfluidics 71

2.5 Development of Driving Forces for Microfluidic Processes 74

2.5.1 Fundamental in Electrokinetic Methods for Microfluidics 76

2.5.2 Basic Principles of Magnetic Field-Coupled Microfluidic Process 81

2.5.3 Basic Principles in Optofluidic Processes for Microfluidics 83

2.6 Construction Materials Considerations 94

Acknowledgments 100

References 100

3 Microfluidics Devices: Fabrication and Surface Modification 113
Zhenfeng Wang and Tao Zhang

3.1 Introduction 113

3.2 Microfluidics Device Fabrication 113

3.2.1 Silicon and Glass Fabrication Process 114

3.2.1.1 Photolithography 117

3.2.1.2 Etching 117

3.2.1.3 Metallization 117

3.2.1.4 Bonding 117

3.2.2 Polymer Fabrication Process 119

3.2.2.1 Patterning 119

3.2.2.2 Bonding 125

3.2.2.3 Metallization 128

3.2.2.4 3D Printing 128

3.2.2.5 Surface Treatment 129

3.2.3 Fabrication for Emerging Microfluidics Devices 129

3.3 Surface Modification in Microfluidics Fabrication 129

3.3.1 Plasma Treatment 132

3.3.2 Surface Modification Using Surfactant 134

3.3.3 Surface Modification with Grafting Polymers 135

3.3.3.1 Surface Photo-Grafting Polymerization 135

3.3.3.2 Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP) 137

3.3.3.3 Grafting-to Technique 142

3.3.4 Nanomaterials for Bulk Modification of Polymers 142

3.4 Conclusions and Outlook 143

References 144

4 Numerical Simulation in Microfluidics and the Introduction of the Related Software 147
Zheng Zhao, Adrian Fisher, and Daojian Cheng

4.1 Introduction 147&l...

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Produktinformationen

Titel
Microfluidics
Untertitel
Fundamentals, Devices, and Applications
Autor
Editor
EAN
9783527800650
ISBN
978-3-527-80065-0
Format
E-Book (epub)
Herausgeber
Wiley-Vch
Genre
Chemie
Veröffentlichung
04.01.2018
Digitaler Kopierschutz
Adobe-DRM
Dateigrösse
35.92 MB
Anzahl Seiten
352
Jahr
2018
Untertitel
Englisch
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