68Ga-DOTATOC/DOTANOC: synthesis and dosimetry

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Beschreibung

Radiolabeled peptides are of increasing interest in nuclear oncology. In recent years, special emphasis has been given to the development of peptides labeled with positron emitters. Among these, 68Ga deserves special attention as an alternative to FDG, because it is available from an inhouse generator rendering 68Ga radiopharmacy independent of an onsite cyclotron. 68Ga has a half-life of 68 min and decays by 89% through positron emission. The parent, 68Ge, is accelerator produced and decays with a half-life of 270.8 days by electron capture. Several bifunctional chelators based on 1,4,7- triazacyclononane-N,N',N''-triacetic acid and 1,4,7,10- tetraazacyclododecane-N,N',N'',N'''- tetraacetic acid (DOTA) macrocycles are available for coupling to peptides and other biomolecules. Clinical studies were performed with 68Ga-DOTA, Tyr3- octreotide, localizing neuroendocrine tumors with higher sensitivity than 111In- diethylenetriaminepentaacetic acid-octreotide. In this study 68Ga-DOTANOC/DOTATOC was prepared using inhouse 68Ge/68Ga generator and radiation exposure was measured to nuclear medicine staff during handling the generator.

Autorentext

Durgesh Kumar Dwivedi a Physicist & a RSO. Masters from the Dept of Nuclear Medicine at AIIMS, New Delhi, INDIA and presently, research scholar in the Dept of NMR & MRI Facility, AIIMS. Currently, trying to develop some of novel techniques for the diagnosis of prostate cancer (using MRI/MRSI/PET/DWI etc).

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Produktinformationen

Titel
68Ga-DOTATOC/DOTANOC: synthesis and dosimetry
Untertitel
PREPARATION OF 68Ga-DOTA-TOC/-NOC FROM 68Ge/68Ga GENERATOR AND THE RADIATION EXPOSURE TO NUCLEAR MEDICINE STAFF DURING HANDLING 68Ge/68Ga GENERATOR
Autor
EAN
9783844310962
ISBN
978-3-8443-1096-2
Format
Kartonierter Einband
Herausgeber
LAP Lambert Academic Publishing
Genre
Medizin
Anzahl Seiten
92
Gewicht
156g
Größe
H5mm x B220mm x T150mm
Jahr
2011
Untertitel
Englisch
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