This book presents a comparison analysis of two cancer treatment therapies: carbon ion therapy and protontherapy. It is divided in 5 sections. The first ones gives the reader a brief history of Radiotherapy and types of radiation. In the second section, the techniques and equipments, including new ones in development such as Cyclinac , Laser and DWA, are described. The third section describes biophysical (such as stopping power and LET) and biological (such as RBE and OER) properties, the fundamental experiments and clinical area. The fourth section presents models and the fifth section compares both techniques, showing advantages and disadvantages of each, and their similarities.
Presents a comparative analysis of two cancer treatments based on ion therapy
Describes new equipments in development such as Cyclinac , Laser and DWA
Special chapter on clinical experiences using the techniquesInhalt
INTRODUCTION.- Brief history of Radiotherapy.- Cancer: Statistical analysis.- Conventional radiotherapy.- Protontherapy.- Carbon ion therapy.- Hadrontherapy Timeline.- EQUIPMENTS AND TECHNIQUES.- The Cyclotron, Ernest Orlando Lawrence / Equations.- The Proton Synchrotron / Equations.- C400 from IBA / Hybrid system. When to use cyclotron or synchrotron: Power and current.- Synchrotron at Loma Linda University Medical Center, Heidelberg, CNAO, NIRS (Japan). PTCOG.- Gantry specifications. Compact gantry.- How to obtain particles (protons, neutrons) and heavy ions for hadron therapy.- Relativistic velocities.- Carbon ion therapy at Berkeley.- Other techniques in development: Dielectric Wall Accelerator and Laser.- Analytical: small samples and different equipment.- ADVANTAGES, DISADVANTAGES, SIMILARITIES. DISCUSSION.- Stopping power.- LET and RBE (determination), Vienna's Congress.- Phanton.- Radiation dose.- Intensity-controlled raster scan method.- Impact of radiation at the microscopic level.- Table. Explanation.- Fluka: a simulation code.- Estimating the risk of second malignancies.- Comments and discussion on Positrons.- WHEN CARBON ION THERAPY MUST BE USED.- Elective indications for carbon ion therapy.- Recurrent tumors.- Children tumors.- Chordoma/chondrosarcoma.- Malignant salivary gland tumors.- Malignant melanoma of the paranasal sinus.- Soft tissue sarcomas and bone tumors.- Early stage lung cancer.- Liver tumors.- Prostate carcinoma.- New centers of carbon ion therapy.