Reviews of Physiology, Biochemistry and Pharmacology 156

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Beschreibung

Gastric acid plays a primary role in digestion as well as in the sterilization of food and water. Gastric juice contains the most concentrated physiological acid solution (pH~1) as a result + of H and Cl ion secretion [hydrochloric acid (HCl) production] by parietal cells in the oxyntic mucosa of the stomach. The combined output of the parietal cells leads to the sec- tion of 12 l of HCl at a concentration of 150160 mmol/l into the interior of the stomach. In order to facilitate the production of acid, the parietal cell relies on the generation of a high + concentration of H ions that are transported into the lumen of the gland. This process is fa- + + cilitated by activation of the gastric H ,K -ATPase, which translocates to the apical pole of + the parietal cell. K as well as ATP hydrolysis and Cl all play critical roles in the activation + + of gastric H ,K -ATPase and are essential for the functioning of the enzyme (Reenstra and Forte 1990). This review will examine the classical proteins that have been linked to acid secretion as well as some recently identi?ed proteins that may modulate gastric acid secretion, in - dition we discuss the known secretagogues, and their receptors including a new receptor, which upon stimulation can lead to acid secretion.

Inhalt
E. A. Craig, P. Huang, R. Aron, and A. Andrew: The diverse roles of J-Proteins, the obligate Hsp70 co-chaperone.- M. Belakavadi and J.D. Fondell: Nuclear hormone receptor signaling.- J.P. Geibel and C. Wagner: An update on acid secretion.- G. Owsianik, D. D'hoedt, T. Voets, and B. Nilius: The TRP channel superfamily.

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Produktinformationen

Titel
Reviews of Physiology, Biochemistry and Pharmacology 156
Editor
EAN
9783642068249
ISBN
3642068243
Format
Kartonierter Einband
Herausgeber
Springer Berlin Heidelberg
Genre
Medizin
Anzahl Seiten
96
Gewicht
160g
Größe
H235mm x B155mm x T5mm
Jahr
2010
Untertitel
Englisch
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