A Novel Enantioselective Synthesis of Spiro-Oxindoles

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Beschreibung

Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.

Autorentext

Sesha Sridevi Alluri- A Doctoral student, working with Prof. A. K. Ganguly at stevens Institute of Technology, NJ, USA. She is a co-inventor on two patents and a recipient of several awards and fellowships.

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Produktinformationen

Titel
A Novel Enantioselective Synthesis of Spiro-Oxindoles
Untertitel
Analogs of Horsifiline and Spirotryprostatin
Autor
EAN
9783838355085
ISBN
978-3-8383-5508-5
Format
Kartonierter Einband
Genre
Chemie
Anzahl Seiten
76
Gewicht
130g
Größe
H220mm x B150mm x T5mm
Jahr
2010
Untertitel
Englisch
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